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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

Received: AugAccepted: JanuPublished: February 5, 2020 (2020) iCARE: An R package to build, validate and apply absolute risk models. We provide an illustration of the utility of iCARE for building, validating and applying absolute risk models using breast cancer as an example.Ĭitation: Pal Choudhury P, Maas P, Wilcox A, Wheeler W, Brook M, Check D, et al.
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The validation component of the software implements the methods for evaluation of model calibration, discrimination and risk-stratification based on independent validation datasets. The software allows single nucleotide polymorphisms (SNPs) to be incorporated into the model using published odds ratios and allele frequencies. The tool can handle missing information on risk factors for individuals for whom risks are to be predicted using a coherent approach where all estimates are derived from a single model after appropriate model averaging.
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An attractive feature of the software is that it gives users flexibility to update models rapidly based on new knowledge on risk factors and tailor models to different populations by specifying three input arguments: a model for relative risk, an age-specific disease incidence rate and the distribution of risk factors for the population of interest.
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If you’ve found a Icaregifts great deal, promo, discount, coupon, or sale you want to share with us, visit our Share your promo code page.This report describes an R package, called the Individualized Coherent Absolute Risk Estimator ( iCARE) tool, that allows researchers to build and evaluate models for absolute risk and apply them to estimate an individual’s risk of developing disease during a specified time interval based on a set of user defined input parameters. How do I submit an Icaregifts promo code? Check the expiry date of the code, as some of them run for a limited time or expire after a set period.

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